Which statement correctly describes Type A ADRs?

Which statement correctly describes Type A ADRs?

• A. They are unpredictable and not dose-related
• B. They are dose-related and predictable
• C. They are rare and time-related
• D. They are immunological reactions

Answer: (B)

Type A adverse drug reactions are augmented responses—exaggerations of the drug’s normal pharmacologic action. They are dose-related and predictable because the more drug you have in the system, the more its usual effects are amplified, so the adverse effects tend to rise with higher doses or longer exposure. This makes them largely preventable by adjusting the dose, slowing titration, or increasing monitoring. Examples include nausea or GI irritation with NSAIDs, or increased sedation with higher doses of benzodiazepines. In contrast, other ADR types are unpredictable and not related to dose, often immune- or idiosyncrasy-driven.

Type A adverse drug reactions are augmented responses—exaggerations of the drug’s normal pharmacologic action. They are dose-related and predictable because the more drug you have in the system, the more its usual effects are amplified, so the adverse effects tend to rise with higher doses or longer exposure. This makes them largely preventable by adjusting the dose, slowing titration, or increasing monitoring. Examples include nausea or GI irritation with NSAIDs, or increased sedation with higher doses of benzodiazepines. In contrast, other ADR types are unpredictable and not related to dose, often immune- or idiosyncrasy-driven.