What defines a Type C ADR?

What defines a Type C ADR?

• A. Chronic, dose related and time related (related to the cumulative dose)
• B. Delayed, time related (becomes apparent sometime after use)
• C. Bizarre, unpredictable
• D. Immediate hypersensitivity

Answer: (A)

Type C adverse drug reactions are the ones that show up after long-term use and depend on the total amount of drug exposure over time. They arise because the body accumulates a dose over weeks, months, or years, so risk grows with duration of therapy and with the cumulative dose, not just with a single, recent dose. This is why these reactions often don’t appear with short courses but become evident only after extended treatment. Examples include effects from chronic corticosteroid use (like osteoporosis or Cushingoid features) or other organ toxicities that emerge with long-term exposure. The other patterns describe reactions that are immediate or unpredictable, or that don’t specifically hinge on cumulative exposure, so they don’t fit the Type C profile.

Type C adverse drug reactions are the ones that show up after long-term use and depend on the total amount of drug exposure over time. They arise because the body accumulates a dose over weeks, months, or years, so risk grows with duration of therapy and with the cumulative dose, not just with a single, recent dose. This is why these reactions often don’t appear with short courses but become evident only after extended treatment. Examples include effects from chronic corticosteroid use (like osteoporosis or Cushingoid features) or other organ toxicities that emerge with long-term exposure. The other patterns describe reactions that are immediate or unpredictable, or that don’t specifically hinge on cumulative exposure, so they don’t fit the Type C profile.