Type E ADRs are withdrawal reactions that occur at what point?

Type E ADRs are withdrawal reactions that occur at what point?

• A. At the end of drug use
• B. During initial therapy
• C. After dose adjustment
• D. Before starting therapy

Answer: (A)

Type E adverse drug reactions are withdrawal symptoms that appear when a drug is stopped after a period of use due to the body’s dependence on the drug. Because the body has adapted to the drug’s presence, removing it triggers rebound or withdrawal effects. These symptoms typically occur at the end of therapy, when treatment is discontinued, rather than during initiation, after dose changes, or before starting therapy. For example, stopping a drug that has produced tolerance and dependence can lead to withdrawal signs like anxiety, tremor, or flu-like symptoms. Therefore, withdrawal ADRs occur at the end of drug use.

Type E adverse drug reactions are withdrawal symptoms that appear when a drug is stopped after a period of use due to the body’s dependence on the drug. Because the body has adapted to the drug’s presence, removing it triggers rebound or withdrawal effects. These symptoms typically occur at the end of therapy, when treatment is discontinued, rather than during initiation, after dose changes, or before starting therapy. For example, stopping a drug that has produced tolerance and dependence can lead to withdrawal signs like anxiety, tremor, or flu-like symptoms. Therefore, withdrawal ADRs occur at the end of drug use.